Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis

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Extracorporeal shock wave therapy induces therapeutic lymphangiogenesis in a rat model of secondary lymphoedema.

OBJECTIVE Lymphoedema is a common complication after cancer treatment. We have reported that low-energy extracorporeal shock wave (SW) therapy up-regulates vascular endothelial growth factor (VEGF) in ischaemic myocardium. As VEGF plays an important role in lymphangiogenesis, we investigated whether our low-energy SW therapy enhances lymphangiogenesis in rats. METHODS We created a tail model ...

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Computed Tomography as an Objective Measurement Tool for Secondary Lymphedema Treated With Extracorporeal Shock Wave Therapy

Two patients with stage three secondary lymphedema of the upper extremities underwent treatment for breast cancer, including surgery, chemotherapy, and radiotherapy. They were examined with computed tomography (CT) before and after extracorporeal shock wave therapy (ESWT). We used a manual tracing method using PiViewSTAR software to calculate the volume of the upper extremities. There was a dec...

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Clinical Outcomes of Extracorporeal Shock Wave Therapy in Patients With Secondary Lymphedema: A Pilot Study

OBJECTIVE To investigate the clinical effect of extracorporeal shock wave therapy (ESWT) in patients with secondary lymphedema after breast cancer treatment. METHODS In a prospective clinical trial, ESWT was performed consecutively 4 times over two weeks in 7 patients who were diagnosed with stage 3 secondary lymphedema after breast cancer treatment. Each patient was treated with four session...

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Extracorporeal Shock Wave Therapy

When extracorporeal shock wave therapy (ESWT) was administered to the equine metacarpus/ metatarsus, there was subperiosteal and subendosteal hemorrhage, but no microfractures were detected. No damage to the surrounding soft tissues was detected. The principle of ESWT and the acute effects of ESWT on equine bone and soft tissue are explained. Authors’ Addresses: Department of Veterinary Clinica...

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VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema.

Although lymphedema is a common clinical condition, treatment for this disabling condition remains limited and largely ineffective. Recently, it has been reported that overexpression of VEGF-C correlates with increased lymphatic vessel growth (lymphangiogenesis). However, the effect of VEGF-C-induced lymphangiogenesis on lymphedema has yet to be demonstrated. Here we investigated the impact of ...

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ژورنال

عنوان ژورنال: Journal of Vascular Surgery

سال: 2010

ISSN: 0741-5214

DOI: 10.1016/j.jvs.2010.03.017